Structural Basis of Inter-Species Barrier to Hepatitis B Viral Entry into Macaque vs Human Liver Cells (IMAGE)

Tokyo University of Science

Structural Basis of Inter-Species Barrier to Hepatitis B Viral Entry into Macaque vs Human Liver Cells

Caption

The figure shows how the hepatitis B virus (HBV) infection is restricted by two sites on the macaque liver cell receptor NTCP. (a) Cryo-electron microscopic structure of macaque NTCP (cyan)-bile acid (orange) complex. (b) Superposing HBV preS1 (red) (PDB: 8HRX) on macaque NTCP (cyan). (c) Asparagine at position 86 (blue) in macaque NTCP is unable to stabilize the HBV preS1 binding. (d) Arginine at position 158 (blue) in macaque NTCP clashes with HBV preS1.

Credit

Koichi Watashi from Tokyo University of Science, Japan Image source link: https://www.nature.com/articles/s41467-024-53533-6

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