How the Antibody K4-66 Binds to SARS-CoV-2 Spike Protein (IMAGE)

Kumamoto University

How the Antibody K4-66 Binds to SARS-CoV-2 Spike Protein

Caption

Cryo-EM analysis on the complex between Fab (Fragment, Antigen-Binding) K4-66 and SARS-CoV-2 XBB.1.5 S ectodomain revealed that K4-66 recognizes the same epitope as previously reported IGHV3-53/3-66 monoclonal antibodies such as CC12.1. However, Fab K4-66 binds at a bonding angle approximately 30°more inclined compared to Fab CC12.1.

 

Credit

Takeo Kuwata, Shuzo Matsushita, Kumamoto University

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