Loss of function mutation in the mitochondrial gene ND5 results in impaired cognitive and metabolism functions (IMAGE)

Korea University College of Medicine

Loss of function mutation in the mitochondrial gene ND5 results in impaired cognitive and metabolism functions

Caption

Researchers employed a programmable DNA base editing technology to introduce a knockout mutation in the ND5 mitochondria gene, aiming to investigate the resulting genotypic and phenotypic changes. This animal model holds significant potential to accelerate therapeutic research for mitochondrial dysfunctions affecting millions worldwide.

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Prof. Hyunji Lee, Associate Professor, Korea University College of Medicine

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