Canonical ligand-dependent and non-canonical ligand-independent EphA2 signaling in the eye lens of wild-type, knockout, and aging mice (IMAGE)
Caption
Figure 11. A summary of the localization and protein levels of canonically active EphA2-pY589 and non-canonically active EphA2-pS898 in control and ephrin-A5-/- lenses from 6-week-old, 4-month-old, and 8-month-old mice. Canonical ligand-mediated EphA2-pY589 is only found in lens epithelial cells, and protein levels do not change with age. Non-canonical ligand-independent activation of EphA2-pS898 is found in epithelial cells and mature fiber cells in the lens cortex. The levels of EphA2-pS898 increase with age, and in ephrin-A5-/- epithelial cells, there is an increase compared to the control in 8-month-old mice. Cartoon not drawn to scale. Modified from [38].
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2024 Horner et al.
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