(IMAGE)
Caption
Figure 3. Docking of ADNP_Glu931Glyfs12 to the PTB protein. (A) The results of docking ADNP_Glu931Glyfs12 (light orange) to the PTB protein (PDB code 3DXC, navy blue) in the 934-941 amino acid region (red)—one of the PTB binding sites within ADNP_Glu931Glyfs12—are presented here. The docking results indicate that the internal NAP (cyan) interacts with the PTB protein through residue 354. (A1) Three measures were used to evaluate the docking as explained in Figure 2A1. (B) The results of docking ADNP_Glu931Glyfs12 (light orange) to the PTB protein (PDB code 3DXC, navy blue) in the 450-457 amino acid region (red)—one of the PTB binding sites within ADNP_Glu931Glyfs12—are presented here. The docking results indicate that the internal NAP (cyan) interacts with the PTB protein through residues 354-357 and 361. (B1) Three measures were used to evaluate the docking as in Figure 2A1. (C) Docking ADNP wild type (light orange) to the PTB protein (PDB code 3DXC, navy blue) in the 450-457 amino acid region (red)—one of the PTB binding sites within ADNP wild type—are presented. The
docking results indicate that the internal NAP (cyan) does not interact with the PTB protein. (C1) As above, three measures were used to evaluate the docking in C as explained in Figure 2A1.
Credit
Illana Gozes. PhD
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND