(IMAGE)
Caption
The ER-phagy receptor FAM134B is initially distributed via the membrane surface (left). Its IDRs move back and forth in a largely disordered manner, like tentacles. The formation of local clusters initiates the curvature of the membrane (2nd from left), which is further strengthened by the condensation of the tentacles into more compact structures (2nd from right). The pinching off of the membrane vesicle (not shown) is initiated by a targeted redistribution of proteins (sorting, right).
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Bhaskara Group, Goethe University Frankfurt
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