TOC abstract (IMAGE) Shanghai Jiao Tong University Journal Center Caption • Microneedle sensors enable minimally invasive and continuous biomarker monitoring through dermal interstitial fluid. • This review offers a comprehensive overview of microneedle sensing technology. • Key topics covered include skin physiology, microneedle design, sensing mechanisms, monitoring electronics, and applications. Credit All authors Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted. License CC BY-NC-ND Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.