Tumor suppressor forms gel-like assemblies to sacrifice cancer cells (IMAGE)

St. Jude Children's Research Hospital

Tumor suppressor forms gel-like assemblies to sacrifice cancer cells

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Corresponding author Richard Kriwacki, PhD, St. Jude Department of Structural Biology, investigated how the tumor suppressor p14ARF undergoes phase separation with nucleophosmin in the nucleolus to form gel-like condensates. This leads to ribosome production arrest and a potentially alternative way p14ARF elicits its tumor suppressor function.

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St. Jude Children's Research Hospital

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