CHiTA (IMAGE) Penn State Caption The novel Cleavage High-throughput Assay (CHiTA) developed at Penn State provides a scarless method to characterize thousands of diverse small self-cleaving RNA enzymes, called twister ribozymes, in a single experiment. The image shows 2D models of some of the tested ribozymes that had imperfections in their helical and loop elements but were still active, demonstrating that twister ribozyme's ability to self-cleave is tolerant of these slight structural imperfections. Credit Lauren McKinley and Philip Bevilacqua, Penn State Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted. License CC BY-NC-ND Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.