(IMAGE) Genomic Press Caption Brain structural (MRI) scans from a selection of individuals from the Lothian Birth Cohort 1936 taken during Wave 2 (when all participants were about 73 years old). Panel A shows global atrophy (brain volumetric shrinkage) ordered from least (top left) to most (bottom right). Panel B shows total white matter hyperintensity volume (increasing from top left to bottom right). Panels A and B are reproduced from Cox and Deary (2022) in Brain Aging, 2, 100032 (74); this article is an open access article distributed under the terms of the Creative Commons CC BY 4.0 license and the figure is reproduced here, with thanks, under that license. Panel C shows white matter pathways of a middle-aged male adult, identified using diffusion MRI. Views from left to right: superior, lateral, anterior, inferior. Credit Ian J. Deary Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted. License CC BY-NC-ND Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.