Schematic diagram of optic-fiber drug delivery system with the drug controlled-release and in-situ monitoring functions (IMAGE)
Caption
a, the fiber-optic therapeutic probe features the minimal invasive nature to target the tumor in vivo. The fiber probe has photothermal therapy, drug delivery and thermally controlled release, temperature and drug release monitoring which can realize synergistic therapy as the pieces of puzzle displayed on the diagram. b, The schematic diagram drug release of optic-fiber therapeutic probe with a Dox@Agarose film. The low-melting agarose carrying Dox are coated on fiber surface, which can be well-reserved under the melting threshold. In the operation, Dox will be precisely released from the agarose film at the tumor lesion as the localized temperature was increased by transmitting the 980 nm pump laser into the fiber probe. c, Principle of the in-situ sensing of the fiber probe. The peak signal of FBG moving to longer wavelength indicates the increasing temperature, and interference signal of MZI shifting to shorter wavelength demonstrated the successful release of drugs. Abbreviations: MZI: Mach–Zehnder interferometer; FBG: Optical fiber Bragg grating; Δλ: wavelength shift.
Credit
by Yongkang Zhang et al.
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License
CC BY