Kidney cells activated during fasting-mimicking diet (IMAGE)

Children's Hospital Los Angeles

Kidney cells activated during fasting-mimicking diet

Caption

Cells expressing PAX8 (nucleus, red) considered podocyte precursors, line the outer Bowman’s capsule. Activated during the low salt-fasting mimicking diet (LS-FMD), the cells migrate and trans-differentiate to podocytes marked by NEPHRIN (cytoplasm, orange). PAX8 and NEPHRIN co-expressing cells were detected within the glomerulus of a nephrotic rat during LS-FMD.

Credit

CHLA, GOFARR Lab

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