Initiation of tumor dormancy by the lymphovascular embolus (IMAGE)
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Figure 8: Schematic of the Mary-X xenograft/spheroidgenesis model of tumor dormancy Schematic depicts the Mary-X xenograft/spheroidgenesis sequence (A–G) which initiates tumor dormancy in vivo within the lymphovascular tumor emboli (C) and in vitro during spontaneous spheroidgenesis (D–G). The latter stages of this sequence result in the release of dormancy when the dormant spheroids (G) are reinjected into mice (H) with the subsequent emergence of Mary-X (I).
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2024 Ye et al.
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