Fig. Overview of the study (IMAGE)

Osaka University

Fig. Overview of the study

Caption

(A) We created unique cells with double the usual number of chromosomes to investigate the relationship between polyploidy and DNA damage.(B) After treatment with the anti-cancer drug cisplatin, polyploid cells accumulated more DNA damage than diploid cells. The bright spots in the image represent DNA damage, visualized by microscopy.(C) Cisplatin kills cancer cells by inducing extensive DNA damage. Despite the higher levels of DNA damage in polyploid cells, they showed greater resistance to cisplatin than diploid cells.

Credit

2024, Tomonori Matsumoto, et al., Cell Death Discovery

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CC BY

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