Involvement of ATP-citrate lyase (ACLY) in the pro-inflammatory senescence-associated secretory phenotype (SASP) in senescent cells. (IMAGE)

Kumamoto University

Involvement of ATP-citrate lyase (ACLY) in the pro-inflammatory senescence-associated secretory phenotype (SASP) in senescent cells.

Caption

ACLY is crucial for establishing and maintaining the pro-inflammatory SASP. The ACLY-BRD4 axis enhances the aging-related inflammatory response. Therefore, inhibiting the ACLY-BRD4 axis helps create the pro-inflammatory microenvironment in senescent cells.

Credit

Mitsuyoshi Nakao, Kan Etoh, Kumamoto University

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