Proposed working model (IMAGE)
Caption
Proposed working model. Progerin accumulation induces stress, leading to attenuation of Ang2 expression and secretion and its downstream effector. Ang2-induced activation of Tie2 receptor activates AKT signaling pathways, which improves HGPS ECs NO production, angiogenesis, survival, migration, and secretome.
Credit
Image courtesy of Sahar Vakili/UMD.
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CC BY-NC-SA