Linking FOXM1 and PD-L1 to CDK4/6-MEK targeted therapy resistance in malignant peripheral nerve sheath tumors (IMAGE)
Caption
Figure 1: Central mechanisms of MPNST progression and therapy resistance. Pathway diagram depicting NF1 loss and hyperactivation of MEK and CDK4/6 kinases as defining events in MPNST formation. FOXM1 and PD-L1 are downstream effectors of MEK and CDK4/6 whose upregulation likely mediates resistance to inhibitors of those kinases. Perpendicular bar, inhibition; Arrow, activation. Figure made with https://www.biorender.com/.
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2024 Lingo et al.
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