Genomic analysis of specific and shared causal variants between bipolar disorder I and epilepsy (IMAGE)
Caption
Genomic analysis of specific and shared causal variants between bipolar disorder I (BD-I) and epilepsy. (A) Venn plot shows the number of specific and shared causal variants between BD-I and epilepsy. The genetic correlation of rg was estimated by Linkage Disequilibrium Score Regression (LDSC). (B) Manhattan plot of conjFDR result. Lead Single Nucleotide Polymorphisms (SNPs) in each independent risk loci with the same direction of allelic effects between BD-I and epilepsy are marked in red, and lead SNPs in each independent risk loci with opposite direction of allelic effects between BD-I and epilepsy are marked in black. (C) LocusZoom plots show the genetic associations with BD-I and epilepsy in the SP4 locus. Physical maps blow the plots depict known genes within the region, and the Linkage Disequilibrium (LD) is defined based on the SNP rs9639379.
Credit
Ming Li, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
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