Graphical Abstract (IMAGE) Shanghai Jiao Tong University Journal Center Caption MSResG effectively integrates multi-source drug features, comprehensively considers the impact of different information contained in different features on model performance. In order to extract more drug information, we built a heterogeneous network containing both DDI information and similarity information. The MSResG‘s performance with standard GCN, PlainGCN and ResGCN are compared when they were used as encoders in ablation experiments. Credit All authors Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted. License CC BY-NC-ND Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.