Understanding a signaling cascade essential for aversive learning (IMAGE)
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This study focused on how NMDAR, an important cell surface receptor, triggers a complex chemical cascade in postsynaptic neurons in the nucleus accumbens region of the brain. More specifically, the researchers used an innovative methodology to investigate phosphorylation events downstream of NMDAR activation, shedding light on the intricacies of the chemistry related to aversive learning in mice.
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Reprinted with permission from Funahashi et al., Science Signaling 17(853):eado9852 (2024).
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