Amyloid aggregation in p63 and p73 biomolecular condensates triggered by oncogenic p53: heparin as an inhibitor (IMAGE)

Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB)

Amyloid aggregation in p63 and p73 biomolecular condensates triggered by oncogenic p53: heparin as an inhibitor

Caption

Schematic illustrating the effects of p53C and M237I in driving the conversion of p63C and p73C droplets into amyloid aggregates at physiologically relevant temperatures. Heparin prevents the formation of p53C/p63C and p53C/p73C aggregates. At 4°C, phase separation occurs without phase transition.

Credit

Guilherme Oliveira

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CC BY-NC

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