A disease-oriented BNM pipeline (IMAGE) Health Data Science Caption A general disease-oriented BNM pipeline is illustrated in this figure. Specifically, diffusion MRI data is processed to obtain individual large-scale connectome with empirical brain SC (top row). Empirical FC is derived from statistical analyses of time-series data from MEG, EEG, or fMRI (bottom left). The BNM is constructed by coupling neural mass models with SC data and supplies the computational neuronal activity for each brain region (bottom right). Then, simulated signals are compared with empirical functional data to estimate the optimal working points and regimes of a virtual brain (bottom centre). Credit Harbin Institute of Technology, Shenzhen Usage Restrictions News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.