Decoding the role of S5, the fifth transmembrane segment in the type 1 ryanodine receptor (RyR1) channel (IMAGE)

Juntendo University Research Promotion Center

Decoding the role of S5, the fifth transmembrane segment in the type 1 ryanodine receptor (RyR1) channel

Caption

S5 mutations disrupt RyR1 channel function, influencing both channel activity and gating mechanisms. This impacts the release of calcium and affects muscle contractions, leading to severe muscle diseases such as malignant hyperthermia and central core disease.

Credit

Associate Professor Takashi Murayama from Juntendo University, Japan and Associate Professor Haruo Ogawa from Kyoto University, Japan

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