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Nara Institute of Science and Technology

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The fruit fly lacks the tRNA nuclear export receptor Exportin-t, which only exports end-processed tRNAs to the cytoplasm to ensure the completion of the processing steps in the nucleus. The related protein Exportin-5 is known to be responsible for tRNA nuclear export in the fly, but whether it is selective for end-processed tRNAs remained unknown. Researchers unexpectedly found that fly Exportin-5 preferentially binds tRNA precursors before end-processing, and end-processing occurs in the cytoplasm after nuclear export of tRNA precursors, unlike the yeast tRNA processing mechanism.

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Katsutomo Okamura

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