Schematic representation of how the gut microbiota contributes to the development of NAFLD (IMAGE)

Xia & He Publishing Inc.

Schematic representation of how the gut microbiota contributes to the development of NAFLD

Caption

In the left panel, the gut-liver axis components are functioning normally. NAFLD is depicted in the right panel. The dysbiotic microbiome, together with the changed intestinal barrier due to the malfunction of the tight junctions, facilitates the translocation of some bacterial products into the portal vein. These bacterial products interact with TLRs on the surface of the hepatic cells, which leads to inflammation and NAFLD development. NAFLD, nonalcoholic fatty liver disease; TLR, Toll-like receptor.

Credit

Subhradip Karmakar, Archana Joon, Anshita Sharma

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

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