Negative for high-grade urothelial carcinoma (NHGUC) (IMAGE)
Caption
Superficial urothelial (umbrella) cells have one or multiple nuclei with finely granular chromatin and conspicuous nucleoli, abundant cytoplasm, and low N/C ratios (a and b). For bladder washing specimens, urothelial cells may be arranged in papillary-like fragments without a fibrovascular core, but with small round or oval nuclei that contains finely granular chromatin, moderate cytoplasm, and low N/C ratios (<0.5) (c). Benign squamous cells are large polygonal cells with abundant dense cytoplasm, small round nuclei that contain finely granular chromatin or dark chromatin, and low N/C ratios (d). Degenerated urothelial cells present with shrunken (condensed), dark nuclei with mildly irregular nuclear borders, granular cytoplasm, and eosinophilic and/or cyanophilic intracytoplasmic inclusions (Melamed-Wolinska bodies) (e). Flat sheet of urothelial cells with low N/C ratios, scant-to-moderate cytoplasm, and small round nuclei that contain finely granular chromatin. Umbrella cells are present on the outer surface (f). Atypical urothelial tissue fragment (AUTF). Clusters of urothelial cells with nuclear overlapping: some had N/C ratios of ≥0.5, and slightly enlarged nuclei with nuclear membrane irregularity and finely granular chromatin (g). Low-grade papillary urothelial carcinoma. Three-dimensional clusters of innocuous urothelial cells with round nuclei, finely granular chromatin and inconspicuous nucleoli, low N/C ratios, and a surrounding fibrovascular core (h). Urolithiasis: clusters of urothelial cells with reactive changes, finely granular chromatin, conspicuous nucleoli, smooth nuclear contours, and low N/C ratios (i). Magnification: ×600.
Credit
Xiaoqi Lin, Fei Chen
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