High-grade prostatic intraepithelial neoplasia (HGPIN) shows flat and papillary growth patterns, with the overlying epithelial cells having enlarged nuclei with prominent nucleoli. (IMAGE)

Xia & He Publishing Inc.

High-grade prostatic intraepithelial neoplasia (HGPIN) shows flat and papillary growth patterns, with the overlying epithelial cells having enlarged nuclei with prominent nucleoli.

Caption

Note benign prostatic glands for comparison on the left (a) (×200). Cribriform pattern is not recognized as HGPIN in the 5th edition. On immunostain, HGPIN is positive for racemase and basal cell markers (CK903 and p63) (b) (×200).

Credit

Charles C. Guo, Bogdan Czerniak

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CC BY-NC

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