A model explaining the mechanism of cellular injury caused by austocystin D (IMAGE)

Tokyo University of Science

A model explaining the mechanism of cellular injury caused by austocystin D

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Previous studies have suggested that austocystin D is oxidized by cytochrome P450 (CYP) oxygenases which then induces DNA damage and suppresses cell proliferation. In this study, we showed that CYP2J2 is required for austocystin D-mediated cellular injury; lysine acetyltransferase 7 (KAT7) promotes CYP2J2 transcription, and PGRMC1 and POR may assist CYP2J2 enzymatic activity. Austocystin D is not easily oxidized in cells with low CYP2J2 expression, and thus does not adversely affect cell proliferation in such cells.

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Professor Mahito Sadaie from Tokyo University of Science

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