PHGDH in breast cancer (IMAGE)
Caption
When fast-growing breast cancer cells run out of glutamine, they turn to an alternative supply line. PHGDH (above, in green) is a key enzyme in that metabolic pathway. CSHL Assistant Professor Michael Lukey has found that when glutamine and PHGDH are simultaneously depleted in breast cancer cells, it stunts their growth.
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Lukey lab/CSHL
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