Condensins and nucleosome–nucleosome interactions differentially constrain chromatin (IMAGE)

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Condensins and nucleosome–nucleosome interactions differentially constrain chromatin

Caption

CAPTION: (Top) Condensins seem to act as a molecular crosslinkers to make loops. (Bottom, left) Condensins (red) locate around chromosome center. (Bottom, right) Nucleosomes around the periphery (those mostly free from condensins) in the Trichostatin A-treated chromosomes, whose nucleosome–nucleosomes interactions are weakened, are less constrained and have higher mobility than those around the axis.

Credit

Sachiko Tamura & Kazuhiro Maeshima, National Institute of Genetics, ROIS

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