Image (IMAGE)

Higher Education Press

Image

Caption

Scarb2 deficiency is associated with alterations in gut microbiota composition and increased intestinal FXR signaling, leading to impairments in lipid absorption and the renewal of the intestinal epithelium. Inhibiting FXR signaling or correcting nutrient deficiency can alleviate neurodegenerative changes in Scarb2-/- mice.

Credit

Yinghui Li, Xingchen Liu, Xue Sun, Hui Li, Shige Wang, Wotu Tian, Chen Xiang, Xuyuan Zhang, Jiajia Zheng, Haifang Wang, Liguo Zhang, Li Cao, Catherine C L Wong, Zhihua Liu

Usage Restrictions

none

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.