Healthy organoids (left) show an organized neurogenic zone (shown in yellow) and neural progenitor cells (shown in red/pink). (IMAGE)

Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Healthy organoids (left) show an organized neurogenic zone (shown in yellow) and neural progenitor cells (shown in red/pink).

Caption

Huntington’s Disease organoids (right) exhibit almost no neural progenitors (red) and also show defects in cellular polarity (yelllow). These defects have been described in the literature in human fetuses with Huntington’s disease.

Credit

Selene Lickefett, Heinrich-Heine-Universität Düsseldorf, Werner Dykstra, Max Delbrück Center

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