Experimental setup and design. (IMAGE)
Caption
(A) Rat hindlimb motion capture for gait analysis. Four markers were attached to the hip joint, knee joint, ankle joint, and foot, respectively, to record the hindlimb’s trajectory. The hindlimb model has been simplified into a stick diagram for joint kinematics analysis: θ1, the hip joint; θ2, the knee joint; θ3, the ankle joint. (B) The biomimetic stimulation of the sciatic nerve and the parameters settings. The SSP was 100 μA in amplitude and 800 μs in width. The 8-channel cuff (8-Ch cuff) was implanted in position 1 or position 2. The kinematic and evoked EMG data were recorded for parameter optimization. (C) Parameter testing was carried out on the anesthetized rats on the treadmill. The hindlimb motion was recorded for evaluation. The relationship between stimulation amplitude and joint response was described by a formula, where i(t) represents the stimulation electric current, θ represents 3 joint angles, and S−1 represents the inverse operation of the sigmoid function.
Credit
Yiran Lang, School of Life Science, Beijing Institute of Technology.
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