Potential Role of Natural Compounds Modulating Bone Formation by Mitochondrial Oxidative Phosphorylation (IMAGE)
Caption
Osteoblasts derived from MSCs are cells required for bone formation. Oxidative phosphorylation produces a lot of ATP and other products including NAD+ and ROS. These factors play important roles in the regulation of osteogenesis through different mechanisms, such as Wnt/β-catenin signaling. Natural compounds including resveratrol and others modulate osteogenesis by regulating oxidative phosphorylation in mitochondria. ATP, adenosine triphosphate; LRP, low-density lipoprotein receptor-related protein; MSC, mesenchymal stem cell; NAD+, nicotinamide adenine dinucleotide; ROS, reactive oxygen species; RUNX2, runt-related transcription factor 2; TCA, tricarboxylic acid cycle; Wnt, Wingless-type MMTV integration site family.
Credit
Liangliang Xu, Meilin Du
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CC BY-NC