Myh11-driven Cre(ER) Knockin Mice specific targeting SMCs for cardiovascular disease research (IMAGE)

Science China Press

Myh11-driven Cre(ER) Knockin Mice specific targeting SMCs for cardiovascular disease research

Caption

A. Experimental strategy of Myh11-Cre genetic tracing mice. B. Immunostaining for ZsGreen and Myh11 on aortas of Myh11 Cre mice. C. Experimental strategy of Myh11-CreER genetic tracing mice. D. Schematic showing the experiment design. E. Whole-mount bright-field and fluorescence view of mutant (Myh11-CreER;Smad4flox/flox;R26-tdT) and control (Myh11-CreER;Smad4flox/+;R26-tdT) aortas (female and male mice). F. Immunostaining for tdT, αSMA, and SMAD4 on aortic sections.

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