The OMEGA and CRISPR Systems (IMAGE)
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The evolutionary pathway connecting the OMEGA system to the CRISPR system.
The OMEGA and CRISPR Systems. A. Architectural representation of typical IS200/IS605 and IS607 transposons, showcasing key elements such as Insertion Sequences Cas9-like component A (IscA), accessory RNA-guided endonuclease IscB; Transposase A (TnpA), accessory RNA-guided endonuclease TnpB; and the recently reported eukaryotic Fanzor system, illustrating their distinctive characteristics. B. Schematic depiction of the proposed "peel-and-paste" transposition mechanism mediated by the TnpA transposase, shedding light on the intricate process. C. Comparative evolution between the IS200/605 and IS607 transposon superfamily-encoded OMEGA systems and CRISPR-Cas systems, highlighting the shared lineage and distinctive features.
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