CRISPR/Cas9 mediated gene editing in PD (IMAGE) Xia & He Publishing Inc. Caption (a) CRISPR/Cas9-based gene editing mechanism in PD; (b) Regulation of transcription using CRISPR and Cas9. AC, activating Cas; dCas9, dead Cas9; Me, methylation; PAM, protospacer adjacent motif; PD, Parkinson’s disease; sgRNA, single guide RNA; CRISPR/Cas9, clustered regularly interspaced short palindromic repeats/CRISPR-associated protein-9. Credit Kusum Yadav, Anam Aslam Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. License CC BY-NC Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.