Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival (IMAGE)
Caption
Figure 4: Specific RNLS epitopes contribute to the highest Electrostatic CSs, based on the TCR CDR3s recovered from the TCGA-SKCM WXS and RNAseq files.
The histograms display the distribution frequency of RNLS amino acid (AA) residues that overlap the TCR CDR3s that represented the highest Electrostatic CSs (Methods). The X-axis represents the AA position for RNLS; the Y-axis represents the number of counts, where each count corresponds to the number of times an AA in RNLS overlaps a CDR3. The arrow denotes the peak distribution frequency corresponding to RP220. The epitope maps were generated using TCR CDR3s obtained from (A) the TCGA-SKCM WXS files and (B) the TCGA-SKCM RNAseq files.
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2024 Zaman et al.
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