TOC abstract (IMAGE) Shanghai Jiao Tong University Journal Center Caption • Dual actions of a single compound with both antibiotic and immunomodulatory effects can suppress inflammation and promote tissue regeneration. • Fast-dissolving microneedle patch enables minimally invasive and local delivery of biodegradable microparticles as distributive depots for sustained release of therapeutics in diseased tissues. Credit All authors Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted. License CC BY-NC-ND Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.