INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death (IMAGE)

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INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death

Caption

Figure 7: Proposed mode of action of INT-1B3/1B3.
INT-1B3/1B3 induces apoptosis and cell death leading to expression of DAMPs, e.g., expression of calreticulin, reduced expression of CD39 and CD73 and thus reduced levels of ATP. Release of DAMPs induces maturation of DC and these DC can activate CD4+, CD8+ and CD4-CD8- T cells upon stimulation. Activated CD4+, CD8+ and CD4-CD8- T cells produce IFNγ, TNFα and granzyme B which leads to cytotoxicity against tumor cells. This illustration was created with https://www.biorender.com/.

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2024 Duurland et al.

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