On the one hand, a high-calorie diet is associated with structural and functional changes in brain structures, particularly in the hypothalamus (IMAGE)
Caption
This is due to epigenetic components: microRNA, histone and DNA methylation, gene mutations that alter the expression and production of the neurotrophic factor BDNF, which interacts with the receptors p75NTR and TrkB. BDNF has a regulatory effect on cholesterol metabolism in the brain. At the same time, there is a link between a disruption of the integrity of the blood-brain barrier, BDNF expression (also in other organs and tissues) and mitochondrial dysfunction. On the other hand, a high-calorie diet and metabolic syndrome in mothers and fathers contribute to fetal developmental disorders and predispose offspring to the development of metabolic syndrome. This pattern is explained by the theory of transgenerational inheritance, which links changes in BDNF expression to the development of metabolic diseases.BDNF, brain-derived neurotrophic factor; p75NTR, p75 neurotrophin receptor; Acetyl-CoA, acetyl coenzyme; TrkB, tropomyosin B kinase receptor.
Credit
Olga Khaziakhmatova, Natalia Todosenko
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