Hepatoblasts begin to differentiate under the action of FOXA and GATA (IMAGE)

Xia & He Publishing Inc.

Hepatoblasts begin to differentiate under the action of FOXA and GATA

Caption

Hepatoblasts differentiate into hepatocytes, large and small cholangiocytes. CK8, CK18, and CK19 are expressed in hepatoblasts. CK8 and CK18 are expressed in hepatocytes at week 6. CK19 is expressed in intrahepatic cholangiocytes. CK7 is expressed in intrahepatic cholangiocytes at week 20. Bcl2 is expressed in small cholangiocytes after final differentiation. P4502E1 is expressed in large cholangiocytes. CK, cytokeratin; Bcl2, B-cell lymphoma 2; HNF, hepatocyte nuclear factor.

Credit

Bo Feng, Zi-Xuan Qiu, Lin-Xiang Huang

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License

CC BY-NC

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