TBC1D1 and its downstream target Rab8a exhibit dynamic interaction with NOX2 forming an energy- responsive complex in macrophages. (IMAGE)
Caption
A diagrammatic illustration represents the proposed model. The energy sensor AMPK becomes less active under energy overload conditions, which leads to hypophosphorylation of TBC1D1. Hypophosphorylated TBC1D1 is more active and converts Rab8a to its GDP-bound form. TBC1D1 and GDP-bound Rab8a interacts with NOX2, and enhances its enzymatic activity to generate ROS, which promotes M1 polarization in macrophages and consequent development of obesity. Art by Qi Wang.
Credit
Art by Qi Wang.
Usage Restrictions
Use with credit.
License
Original content