TaSRT2 recognizes a viral protein to activate host immunity by increasing histone acetylation (IMAGE)

Science China Press

TaSRT2 recognizes a viral protein to activate host immunity by increasing histone acetylation

Caption

TaSRT2 recognized viral protein P153 to retain itself in the cytoplasm and reduce its enzymatic activity in defense of CWMV infection. The interaction between TaSRT2 and P153 is critical for the induced wheat resistance to CWMV through inhibition of the TaSRT2-mediated deacetylation of H3K9ac and H3K79ac, which eventually activated the expression of defense-related genes TaLRR1, TaRGA3, and TaWRKY41 that regulated by transcription activators TaERF1 and TaERF039.

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