Illustration of nanoparticle iron oxide regulating gut microbiota to influence cochlear inflammation. (IMAGE)
Caption
Noise can lead to gut microbiota dysbiosis, resulting in an increase in various harmful bacteria and oxidative stress levels within the gut. Pro-inflammatory factors produced by harmful bacteria are transported to the cochlea via the bloodstream, causing elevated inflammation levels in the cochlea and leading to hearing loss. SPIOCA inhibits noise-induced gut microbiota dysbiosis, helps maintain the integrity of the gut barrier, and thus prevents the transport of pro-inflammatory factors to the cochlea. Additionally, SPIOCA specifically induces an increase in sphingolipid-producing Bacteroides, thereby regulating sphingolipid metabolism within the gut-ear axis, further enhancing its protective effect on hearing.
Credit
©Science China Press
Usage Restrictions
Use with credit.
License
Original content