Mechanisms of sorafenib resistance in HCC. (IMAGE)
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Complex mechanisms lie in the resistance to sorafenib in HCC. Not only do they include aspects of epigenetics such as circRNA-SORE, lncRNA SNHG3, and METTL3-mediated processes, but transporters like ABC and exosomes are also involved in resistance. Additionally, from regulated cell death, represented by ferroptosis and autophagy, to tumor metabolic reprogramming, and factors like TAK1 and PCSK9 have also been found to participate in HCC's resistance to sorafenib. By figdraw
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