The design of bispecific CAR-T cells targeting both BCMA and CD19 for depleting B cells (IMAGE)
Caption
Schematic illustration explaining the working principle of BCMA-CD19 bispecific CAR T cells used in current study. CD19 is the pan B cell marker but not expressed in long-lived plasma cells and BCMA is expressed in plasma blasts and long-lived plasma cells. The bispecific BCMA-CD19 CAR-T cells containing anti-BCMA single chain variable fragment (scFv) and anti-CD19 scFv in tandem, linked by GGGGS×4, could cover almost all stages of the B-cell compartment.
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Junnian Zheng, the Affiliated Hospital of Xuzhou Medical University
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