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The University of Hong Kong

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Cell-selective MACSPI analysis in C. elegans. (A) Chemical structure and functions of photo-ANA. (B) A chemical proteomics approach to profile cell type-specific proteome and interactome. (C) Spatial selectivity is achieved by controlling the expression of the MetRS mutant, which can label proteins with photo-ANA, using cell-specific promoters in transgenic animals. Adapted from Huang et al., 2024, PNAS.

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The University of Hong Kong

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