Autoradiography images of GPA33(+) SW1222 xenograft sections acquired using an ionizing-radiation quantum imaging detector (iQID) camera. (IMAGE)
Caption
Figure 1. Autoradiography images of GPA33(+) SW1222 xenograft sections acquired using an ionizing-radiation quantum imaging detector (iQID) camera. The images effectively illustrate that the DOTA-PRIT (DOTA pretargeted radioimmunotherapy) approach can be used to simultaneously deliver 225Ac and 177Lu to tumors. Mice were injected with 177Lu- or 225Ac-radioligand alone (first and second row, respectively), or a 177Lu/225Ac mixture (row 3 and 4), after pretargeting with anti-GPA33/anti-DOTA bispecific antibody. First column shows the combined signal (177Lu and 225Ac together), second column (⍺-counts) shows uptake of 225Ac, and third column (β-counts) show 177Lu-uptake. Fourth column shows an overlay of the 225Ac-signal (red) and 177Lu-signal (green).
Credit
Image courtesy of Rinne et al., Weill Cornell Medicine, New York, New York.
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