Proposed mechanism of action for ISM1 in regulating pulmonary fibrosis development and resolution using BIPF (IMAGE)
Caption
During fibrosis progression, Ism1-/- mice exhibited enhanced cellular senescence in the alveolar type II epithelial (AT2) cells with increased release of senescence associated pro-inflammatory factors which lead to enhanced immune cell infiltration, release of pro-fibrotic mediators promoting the activation of myofibroblasts with excessive collagen deposition, resulting in enhanced bleomycin induced pulmonary fibrosis (BIPF). During fibrosis resolution, reduced lipid synthesis genes and decreased trans-differentiation of myofibroblasts to lipofibroblasts leads to delayed fibrosis resolution in Ism1-/- mice. This figure was generated using BioRender.
Credit
Ruowen Ge, National University of Singapore
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